In the general adaptation syndrome, the stage of resistance is characterized by

Stress typically describes a negative concept that can have an impact on one's mental and physical well-being, but it is unclear what exactly defines stress and whether or not stress is a cause, an effect, or the process connecting the two. With organisms as complex as humans, stress can take on entirely concrete or abstract meanings with highly subjective qualities, satisfying definitions of both cause and effect in ways that can be both tangible and intangible.

Physiologists define stress as how the body reacts to a stressor (any stimulus that causes stress), real or imagined. Acute stressors affect an organism in the short term; chronic stressors over the long term.

Alarm Stage

Alarm is the first stage, which is divided into two phases: the shock phase and the anti-shock phase.

Shock Phase

During this phase, the body can endure changes such as hypovolemia, hypoosmolarity, hyponatremia, hypochloremia, and hypoglycemia—the stressor effect. The organism's resistance to the stressor drops temporarily below the normal range and some level of shock (e.g., circulatory shock) may be experienced.

Anti-Shock Phase

When the threat or stressor is identified or realized, the body starts to respond and is in a state of alarm. During this stage, the locus coeruleus/sympathetic nervous system is activated and catecholamines such as adrenaline are produced to create the fight-or-flight response. 

The result is: increased muscular tonus, increased bloodpressure due to peripheral vasoconstriction and tachycardia, and increased glucose in blood. There is also some activation of the HPA axis, producing glucocorticoids such as cortisol.

Resistance Stage

Resistance is the second stage and the increased secretion of glucocorticoids plays a major role by intensifying the systemic response. This response has lypolytic, catabolic, and antianabolic effects: increased glucose, fat and amino acid/protein concentration in blood. 

Moreover, these effects cause lymphocytopenia, eosinopenia, neutrophilia, and polycythemia. In high doses, cortisol begins to act as a mineralocorticoid (aldosteron) and brings the body to a state similar to hyperaldosteronism. 

If the stressor persists, it becomes necessary to attempt some means of coping with the stress. Although the body begins to try to adapt to the strains or demands of the environment, the body cannot keep this up indefinitely, so its resources are gradually depleted.

Exhaustion or Recovery Stage

The third stage is either exhaustion or recovery.

In the general adaptation syndrome, the stage of resistance is characterized by

General adaptation syndrome

Resistance reaction is the second stage of the general adaptation syndrome and is characterized by a heightened resistance to a stressor. 

This is a diagram of general adaptation syndrome. It shows resistance to stress over time, with the alarm stage building up resistance until it reaches the resistance stage. Resistance continues to build up and peak in the resistance stage, until it declines into the exhaustion stage.

Sanesco Blog

  • May 16, 2016
  • By Annabelle Bennett

  • 2 minute read

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Hans Selye is an internationally renowned medical researcher from the mid-1930s to the late 1970s. Dr. Selye coined the concept of General Adaptation Syndrome (GAS), otherwise known as the “stress response.” An M.D. holding a Ph.D., DSc, and FRS, Dr. Selye solely authored 32 books and wrote over 1500 original and review articles in the fields of endocrinology, steroid chemistry, experimental surgery, and pathology. This short blog simplifies the components of the General Adaptation Syndrome stages and lists some supplements that may prove beneficial in reversing some harmful effects of the stress response.

Three Phases of General Adaptation Syndrome

Dr. Selye’s General Adaptation Syndrome involves three phases: Alarm Phase, Stage of Resistance, and Stage of Exhaustion.

In the general adaptation syndrome, the stage of resistance is characterized by

Stage of Alarm

Body’s immediate response to stress

  • Cortisol is elevated
  • DHEA is elevated

Common symptoms for this portion of the General Adaptation Syndrome stages:

  • Tissue catabolism
  • Low blood glucose levels
  • Gastro-intestinal erosions
  • Sleep issues

Stage of Resistance

This stage is initiated by the pregnenolone steal in which cortisol is made at the expense of DHEA to sustain adaptability.

  • Cortisol is elevated
  • DHEA is decreased
  • Epinephrine may be increased to help sustain energy and blood sugar levels

Common symptoms for this portion of the General Adaptation Syndrome stages:

  • Sleep issues, due to high cortisol
  • Some people stay in this phase for a lifetime, while others further deteriorate

Stage of Exhaustion

The body loses the ability to adapt/body is burnt out from stress.

  • Cortisol is low
  • DHEA is low
  • Epinephrine is low

Common symptoms for this portion of the General Adaptation Syndrome stages:

  • Severe fatigue
  • Allergies
  • Inability to sleep through the night
  • Salt cravings

Supplements to Restore Depleted Adrenal Reserves

  • Panax ginseng (Korean ginseng)
  • Eleutherococcus senticosus
  • Glycyrrhiza glabra (licorice)
  • Ashwagandha
  • Rhodiola rosea
  • Adrenal cortex glandular
  • B complex
  • Vitamin C

References:

  1. Head, KA and Kelly, GS. (2009). Nutrients and Botanicals for Treatment of Stress: Adrenal Fatigue, Neurotransmitter Imbalance, Anxiety, and Restless Sleep. Alternative Medicine Review, 14 (2), 114 – 140.
  2. Selye, H. (1950). Stress and the General Adaptation Syndrome. British Medical Journal, 1 (4667), 1383 – 1392.
  3. Szabo S, Tache Y, and Somogyi A. (2012). The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief “Letter” to the Editor of Nature. Stress, 15 (5), 472 – 478

Annabelle Bennett

Annabelle Bennett is a Clinical Support Specialist at Sanesco. She is a recent Clemson University alumnus with a Bachelors of Science in Biological Sciences. She enjoys getting her dopamine boosts from coffee, the beach, and her two little dogs.

Disclaimer: The information provided is only intended to be general educational information to the public. It does not constitute medical advice. If you have specific questions about any medical matter or if you are suffering from any medical condition, you should consult your doctor or other professional healthcare provider.

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What is the resistance stage of the general adaptation syndrome?

The resistance stage of general adaptation syndrome is when your body tries to repair itself after the initial shock of stress. If the stressful situation is no longer present and you can overcome the stress, your heart and blood pressure will start to return to prestress levels during this stage.

What happens during the resistance stage of the general adaptation syndrome quizlet?

What happens in the resistance stage of GAS according to Selye? The body confronts the threat and resistance is high- if the stressor persists, the body recovers from the alarm stage and begins to cope.

Which stage of the general adaptation syndrome is characterized by quizlet?

The first stage of the General Adaptation Syndrome, characterized by sympathetic arousal and mental clarity. A model that sees health as the result of biological, psychological, and social factors. A hormone released into the bloodstream from the adrenal glands.

What is the resistance stage?

Resistance stage After the initial shock of a stressful event and having a fight-or-flight response, the body begins to repair itself. It releases a lower amount of cortisol, and your heart rate and blood pressure begin to normalize. Although your body enters this recovery phase, it remains on high alert for a while.