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Jaundice refers to the yellow discolouration of the sclera and skin (Fig. 1) that is due to hyperbilirubinaemia, occurring at bilirubin levels roughly greater than 50 µmol/L. Adobe Stock, Licensed to TeachMeSeries Ltd Figure 1 – Yellowing of the sclera PathophysiologyJaundice results from high levels of bilirubin in the blood. Bilirubin is the normal breakdown product from the catabolism of haem, and thus is formed from the destruction of red blood cells. Under normal circumstances, bilirubin undergoes conjugation within the liver, making it water-soluble. It is then excreted via the bile into the GI tract, the majority of which is egested in the faeces as urobilinogen and stercobilin (the metabolic breakdown product of urobilingoen). Around 10% of urobilinogen is reabsorbed into the bloodstream and excreted through the kidneys. Jaundice occurs when this pathway is disrupted. By Johndheathcote [CC BY-SA 3.0], via Wikimedia Commons Figure 2 – Bilirubin is produced as a byproduct of haem metabolism Types of JaundiceThere are three main types of jaundice: pre-hepatic, hepatocellular, and post-hepatic. Pre-Hepatic In pre-hepatic jaundice, there is excessive red cell breakdown which overwhelms the liver’s ability to conjugate bilirubin. This causes an unconjugated hyperbilirubinaemia. Any bilirubin that manages to become conjugated will be excreted normally, yet it is the unconjugated bilirubin that remains in the blood stream to cause the jaundice. Hepatocellular In hepatocellular (or intrahepatic) jaundice, there is dysfunction of the hepatic cells. The liver loses the ability to conjugate bilirubin, but in cases where it also may become cirrhotic, it compresses the intra-hepatic portions of the biliary tree to cause a degree of obstruction. This leads to both unconjugated and conjugated bilirubin in the blood, termed a ‘mixed picture’. Post-Hepatic Post-hepatic jaundice refers to obstruction of biliary drainage. The bilirubin that is not excreted will have been conjugated by the liver, hence the result is a conjugated hyperbilirubinaemia.
Table 1 – Potential Causes for Jaundice, divided into pre-hepatic, hepatocellular, and post-hepatic BilirubinuriaA good estimation of which type of jaundice is present (prior to any further investigation) can be made from observing the colour of the urine. Conjugated bilirubin can be excreted via the urine (as it is water soluble), whereas unconjugated cannot. Consequently, dark (‘coca-cola’) urine manifests in conjugated or mixed hyperbilirubinaemias, whereas normal urine is seen in unconjugated disease. Moreover, those with an obstructive picture will likely note pale stools, due to the reduced levels of stercobilin entering the GI tract, which normally colours the stool. InvestigationsIn many cases, the likely underlying cause can be elicited from the history, with the investigations simply confirming suspicions. Hence, whilst a complete list of investigations is given below, these should be tailored to the clinical features of the patient. Laboratory TestsAny patient presenting with jaundice should have the following bloods taken:
Table 2 – LFT serum markers. *as an estimate, if the AST:ALT ratio >2, this is likely alcoholic liver disease, whilst if AST:ALT is around 1, then likely viral hepatitis as the cause Liver ScreenA liver screen can be performed for patients whereby there is no initial cause for liver dysfunction, tailored to whether acute or chronic liver failure
Table 3 – Acute and Chronic Liver Screens *Autoantibodies include anti-mitochondrial antibody (AMA), anti-smooth-muscle antibody (Anti-SMA), and anti-nuclear antibody (ANA), used to identify a variety of autoimmune liver conditions, such as primary sclerosing cholangitis (PSC) ImagingThe imaging used will depend on the presumed aetiology. An ultrasound abdomen is usually first line, identifying any obstructive pathology present or gross liver pathology (albeit often user dependent). Magnetic Resonance Cholangiopancreatography (MRCP) is used to visual the biliary tree, typically performed if the jaundice is obstructive, but US abdomen was inconclusive or limited, or as further work-up for surgical intervention. A liver biopsy can be performed when the diagnosis has not been made despite the above investigations. ManagementThe definitive treatment of jaundice will be dependent on the underlying cause. Obstructive causes may require removal of a gallstone through Endoscopic Retrograde CholangioPancreatography (ERCP) or stenting of the common bile duct. Symptomatic treatment is often needed for the itching caused by hyperbilirubinaemia. An obstructive cause may warrant cholestyramine (acting to increase biliary drainage), whilst other causes may respond to simple anti-histamines. Identify and manage any complications where possible. Monitor for coagulopathy, treating promptly (either vitamin K or fresh frozen plasma (FFP) is needed) if any evidence of bleeding or rapid coagulopathy, and treat hypoglycaemia orally if possible (otherwise 5% dextrose is needed). Where patients become confused from decompensating chronic liver disease (‘hepatic encephalopathy’), laxatives (lactulose or senna) +/- neomycin or rifaximin may be used, in attempt to reduce the number of ammonia-producing bacteria in the bowel. By User:Pschemp [CC-BY-SA-3.0], via Wikimedia Commons Figure 3 – Images from a laparoscopic cholecystectomy Key Points
Which type of jaundice seen in adults is the result of increased destruction of red blood cells *?Group of diseases related to red blood cells (Pre-hepatic jaundice): The condition in which red blood cells are destroyed at an accelerated rate due to disease, causing bilirubin to be overproduced compared to normal and circulating in the blood, which will cause liver cells to not be able to metabolize this large ...
What are the 3 types of jaundice?Jaundice is the yellowing of the skin and sclera due to abnormally elevated levels of bilirubin in the blood. It can be characterized into three different categories including pre-hepatic, intra-hepatic, or post-hepatic.
Which jaundice is breakdown of red blood cells take place?jaundice from hemolysis: a condition that results from the breakdown of red blood cells due to hemolytic disease of the newborn (Rh disease), polycythemia, or hemorrhage.
What causes jaundice conjugated or unconjugated bilirubin?The predominant causes of conjugated hyperbilirubinemia are intrahepatic cholestasis and extrahepatic obstruction of the biliary tract, with the latter preventing bilirubin from moving into the intestines. Viruses, alcohol, and autoimmune disorders are the most common causes of hepatitis.
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