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Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

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Komazawa Y, Adachi K, Mihara T, et al. Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection. J Gastroenterol Hepatol 2003;18:678-682.

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Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Iwakiri K, Kinoshita Y, Habu Y, et al. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015. J Gastroenterol 2016;51:751-767.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Lanas A. We are using too many PPIs, and we need to stop: a European perspective. Am J Gastroenterol 2016;111:1085-1086.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Fujisawa T, Adachi K, Komazawa Y, et al. Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists. Aliment Pharmacol Ther 2004;20:559-565.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Adachi K, Komazawa Y, Mihara T, et al. Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and famotidine. J Gastroenterol Hepatol 2005;20:1012-1015.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Shin JM, Inatomi N, Munson K, et al. Characterization of a novel potassium-competitive acid blocker of the gastric H,K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438). J Pharmacol Exp Ther 2011;339:412-420.

  • Scott DR, Munson KB, Marcus EA, Lambrecht NW, Sachs G. The binding selectivity of vonoprazan (TAK-438) to the gastric H+, K+-ATPase. Aliment Pharmacol Ther 2015;42:1315-1326.

  • Sakurai Y, Nishimura A, Kennedy G, et al. Safety, Tolerability, pharmacokinetics, and pharmacodynamics of single rising TAK-438 (vonoprazan) doses in healthy male Japanese/non-Japanese subjects. Clin Transl Gastroenterol 2015;6:e94.

  • Sakurai Y, Mori Y, Okamoto H, et al. Acid-inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects--a randomised open-label cross-over study. Aliment Pharmacol Ther 2015;42:719-730.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Ashida K, Sakurai Y, Hori T, et al. Randomised clinical trial: vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis. Aliment Pharmacol Ther 2016;43:240-251.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Murakami K, Sakurai Y, Shiino M, Funao N, Nishimura A, Asaka M. Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study. Gut 2016;65:1439-1446.

  • Kahrilas PJ, Dent J, Lauritsen K, et al. A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clin Gastroenterol Hepatol 2007;5:1385-1391.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Dent J, Kahrilas PJ, Hatlebakk J, et al. A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease. Am J Gastroenterol 2008;103:20-26.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Shirai N, Furuta T, Moriyama Y, et al. Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH. Aliment Pharmacol Ther 2001;15:1929-1937.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Adachi K, Katsube T, Kawamura A, et al. CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole. Aliment Pharmacol Ther 2000;14:1259-1266.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Gedda K, Scott D, Besancon M, Lorentzon P, Sachs G. Turnover of the gastric H+, K+-adenosine triphosphatase alpha subunit and its effect on inhibition of rat gastric acid secretion. Gastroenterology 1995;109:1134-1141.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Huber R, Kohl B, Sachs G, Senn-Bilfinger J, Simon WA, Sturm E. Review article: the continuing development of proton pump inhibitors with particular reference to pantoprazole. Aliment Pharmacol Ther 1995;9:363-378.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Katsube T, Adachi K, Kawamura A, et al. Helicobacter pylori infection influences nocturnal gastric acid breakthrough. Aliment Pharmacol Ther 2000;14:1049-1056.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Hongo M, Fujimoto K, Gastric Polyps Study Group. Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan. J Gastroenterol 2010;45:618-624.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Labenz J, Armstrong D, Lauritsen K, et al. Esomeprazole 20 mg vs. pantoprazole 20 mg for maintenance therapy of healed erosive oesophagitis: results from the EXPO study. Aliment Pharmacol Ther 2005;22:803-811.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Kinoshita Y, Kato M, Fujishiro M, et al. Efficacy and safety of twice-daily rabeprazole maintenance therapy for patients with reflux esophagitis refractory to standard once-daily proton pump inhibitor: the Japan-based EXTEND study. J Gastroenterol 2017;28:1-11.

  • Sugano K, Choi MG, Lin JT, et al. Multinational, double-blind, randomised, placebo-controlled, prospective study of esomeprazole in the prevention of recurrent peptic ulcer in low-dose acetylsalicylic acid users: the LAVENDER study. Gut 2014;63:1061-1068.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Sugano K, Kinoshita Y, Miwa H, Takeuchi T, Esomeprazole NSAID Preventive Study Group. Randomised clinical trial: esomeprazole for the prevention of nonsteroidal anti-inflammatory drug-related peptic ulcers in Japanese patients. Aliment Pharmacol Ther 2012;36:115-125.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Pace F, Annese V, Prada A, et al. Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole. Dig Liver Dis 2005;37:741-750.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999;45:172-180.

  • Singh S, Garg SK, Singh PP, Iyer PG, El-Serag HB. Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett’s oesophagus: a systematic review and meta-analysis. Gut 2014;63:1229-1237.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Hawkey CJ, Karrasch JA, Szczepañski L, et al. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus misoprostol for NSAID-induced ulcer management (OMNIUM) study group. N Engl J Med 1998;338:727-734.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Yeomans ND, Tulassay Z, Juhász L, et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid suppression trial: ranitidine versus omeprazole for NSAID-associated ulcer treatment (ASTRONAUT) study group. N Engl J Med 1998;338:719-726.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Sugano K, Kontani T, Katsuo S, et al. Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. J Gastroenterol 2012;47:540-552.

  • Choi SW, Han JM, Bae YJ, et al. Lessons from two cases of anaphylaxis to proton pump inhibitors. J Clin Pharm Ther 2012;37:614-616.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Dury S, Nardi J, Gozalo C, Lebargy F, Deslee G. Agranulocytosis induced by proton pump inhibitors. J Clin Gastroenterol 2012;46:859.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Zaccardi F, Pitocco D, Martini F, et al. A case of esomeprazole-induced transient diabetes and hepatitis: the role of liver inflammation in the pathogenesis of insulin resistance. Acta Diabetol 2014;51:151-153.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Lin CY, Wang CW, Hui CR, et al. Delayed-type hypersensitivity reactions induced by proton pump inhibitors: a clinical and in vitro T-cell reactivity study. Allergy 2017;73:221-229.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Tröger U, Reiche I, Jepsen MS, Huth C, Bode-Böger SM. Esomeprazole-induced rhabdomyolysis in a patient with heart failure. Intensive Care Med 2010;36:1278-1279.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Shimura S, Hamamoto N, Yoshino N, et al. Diarrhea caused by proton pump inhibitor administration: comparisons among lansoprazole, rabeprazole, and omeprazole. Curr Ther Res Clin Exp 2012;73:112-120.

  • Keszthelyi D, Jansen SV, Schouten GA, et al. Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study. Aliment Pharmacol Ther 2010;32:1124-1128.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Umeno J, Esaki M, Nuki Y, Kim H, Kitazono T, Matsumoto T. Letter: lansoprazole consumption is more common in Japanese patients with collagenous colitis. Aliment Pharmacol Ther 2013;38:208-209.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Mori S, Kadochi Y, Luo Y, et al. Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis. World J Gastroenterol 2017;23:1586-1593.

  • Capurso G, Marignani M, Attilia F, et al. Lansoprazole-induced microscopic colitis: an increasing problem? Results of a prospective case-series and systematic review of the literature. Dig Liver Dis 2011;43:380-385.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Torpey N, Barker T, Ross C. Drug-induced tubulo-interstitial nephritis secondary to proton pump inhibitors: experience from a single UK renal unit. Nephrol Dial Transplant 2004;19:1441-1446.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Berney-Meyer L, Hung N, Slatter T, Schollum JB, Kitching AR, Walker RJ. Omeprazole-induced acute interstitial nephritis: a possible Th1–Th17-mediated injury?. Nephrology (Carlton) 2014;19:359-365.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Muriithi AK, Leung N, Valeri AM, et al. Biopsy-proven acute interstitial nephritis, 1993–2011: a case series. Am J Kidney Dis 2014;64:558-566.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Lazarus B, Chen Y, Wilson FP, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med 2016;176:238-246.

  • Xie Y, Bowe B, Li T, Xian H, Balasubramanian S, Al-Aly Z. Proton pump inhibitors and risk of incident CKD and progression to ESRD. J Am Soc Nephrol 2016;27:3153-3163.

  • Arora P, Gupta A, Golzy M, Patel N, Carter RL, Jalal K, Lohr JW. Proton pump inhibitors are associated with increased risk of development of chronic kidney disease. BMC Nephrol 2016;17:112.

  • Klatte DCF, Gasparini A, Xu H, et al. Association between proton pump inhibitor use and risk of progression of chronic kidney disease. Gastroenterology 2017;153:702-710.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Nochaiwong S, Ruengorn C, Awiphan R, et al. The association between proton pump inhibitor use and the risk of adverse kidney outcomes: a systematic review and meta-analysis. Nephrol Dial Transplant 2017;33:331-342.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Moledina DG, Perazella MA. PPIs and kidney disease: from AIN to CKD. J Nephrol 2016;29:611-616.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Chen J, Chen S, Lian J, Zeng X, Luo T. Pharmacodynamic impacts of proton pump inhibitors on the efficacy of clopidogrel in vivo-a systematic review. Clin Cardiol 2013;36:184-189.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Funck-Brentano C, Szymezak J, Steichen O, et al. Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers. Arch Cardiovasc Dis 2013;106:661-671.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Hokimoto S, Mizobe M, Akasaka T, et al. Impact of CYP2C19 polymorphism and proton pump inhibitors on platelet reactivity to clopidogrel and clinical outcomes following stent implantation. Thrombosis Research 2014;133:599-605.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Zhu P, Gao Z, Tang XF, et al. Impact of proton-pump inhibitors on the pharmacodynamic effect and clinical outcomes in patients receiving dual antiplatelet therapy after percutaneous coronary intervention: a propensity score analysis. Chin Med J 2017;130:2899-2905.

  • Ho PM, Maddox TM, Wang L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA 2009;301:937-944.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • O’Donoghue ML, Braunwald E, Antman EM, et al. Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet 2009;374:989-997.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Simon T, Steg PG, Gilard M, et al. Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French registry of acute ST-elevation and non-ST-elevation myocardial infarction (FAST-MI) registry. Circulation 2011;123:474-482.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Serbin MA, Guzauskas GF, Veenstra DL. Clopidogrel-proton pump inhibitor drug-drug interaction and risk of adverse clinical outcomes among PCI-treated ACS patients: a meta-analysis. J Manag Care Spec Pharm 2016;22:939-947.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Melloni C, Washam JB, Jones WS, et al. Conflicting results between randomized trials and observational studies on the impact of proton pump inhibitors on cardiovascular events when coadministered with dual antiplatelet therapy: systematic review. Circ Cardiovasc Qual Outcomes 2015;8:47-55.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Bhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med 2010;363:1909-1917.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Gao QP, Sun Y, Sun YX, Wang LF, Fu L. Early use of omeprazole benefits patients with acute myocardial infarction. J Thromb Thrombolysis 2009;28:282-287.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Ren YH, Zhao M, Chen YD, et al. Omeprazole affects clopidogrel efficacy but not ischemic events in patients with acute coronary syndrome undergoing elective percutaneous coronary intervention. Chin Med J 2011;124:856-861.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Haenisch B, von Holt K, Wiese B, et al. Risk of dementia in elderly patients with the use of proton pump inhibitors. Eur Arch Psychiatry Clin Neurosci 2015;265:419-428.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Gomm W, von Holt K, Thomé F, et al. Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurol 2016;73:410-416.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Badiola N, Alcalde V, Pujol A, et al. The proton-pump inhibitor lansoprazole enhances amyloid beta production. PLoS One 2013;8:e58837.

  • Lochhead P, Hagan K, Joshi AD, et al. Association between proton pump inhibitor use and cognitive function in women. Gastroenterology 2017;153:971-979, e4.

  • Goldstein FC, Steenland K, Zhao L, Wharton W, Levey AI, Hajjar I. Proton pump inhibitors and risk of mild cognitive impairment and dementia. J Am Geriatr Soc 2017;65:1969-1974.

  • Taipale H, Tolppanen AM, Tiihonen M, Tanskanen A, Tiihonen J, Hartikainen S. No association between proton pump inhibitor use and risk of Alzheimer’s disease. Am J Gastroenterol 2017;112:1802-1808.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Gray SL, Walker RL, Dublin S, et al. Proton pump inhibitor use and dementia risk: prospective population-based study. J Am Geriatr Soc 2017;66:247-253.

  • Wang YF, Chen YT, Luo JC, Chen TJ, Wu JC, Wang SJ. Proton-pump inhibitor use and the risk of first-time ischemic stroke in the general population: a nationwide population-based study. Am J Gastroenterol 2017;112:1084-1093.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Shah NH, LePendu P, Bauer-Mehren A, et al. Proton pump inhibitor usage and the risk of myocardial infarction in the general population. PLoS One 2015;10:e0124653.

  • Tsai CF, Chen MH, Wang YP, et al. Proton pump inhibitors increase risk for hepatic encephalopathy in patients with cirrhosis in a population study. Gastroenterology 2017;152:134-141.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Xie Y, Bowe B, Li T, Xian H, Yan Y, Al-Aly Z. Risk of death among users of proton pump inhibitors: a longitudinal observational cohort study of United States veterans. BMJ Open 2017;7:e015735.

  • Vaezi MF, Yang YX, Howden CW. Complications of proton pump inhibitor therapy. Gastroenterology 2017;153:35-48.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Bjorkman DJ. Proton pump inhibitors and chronic kidney disease: causation or another false alarm?. Gastroenterology 2017;153:638-640.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Liu W, Baker SS, Trinidad J, et al. Inhibition of lysosomal enzyme activities by proton pump inhibitors. J Gastroenterol 2013;48:1343-1352.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA 2004;292:1955-1960.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Gulmez SE, Holm A, Frederiksen H, Jensen TG, Pedersen C, Hallas J. Use of proton pump inhibitors and the risk of community-acquired pneumonia: a population-based case-control study. Arch Intern Med 2007;167:950-955.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Sarkar M, Hennessy S, Yang YX. Proton-pump inhibitor use and the risk for community-acquired pneumonia. Ann Intern Med 2008;149:391-398.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Johnstone J, Nerenberg K, Loeb M. Meta-analysis: proton pump inhibitor use and the risk of community-acquired pneumonia. Aliment Pharmacol Ther 2010;31:1165-1177.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Estborn L, Joelson S. Occurrence of community-acquired respiratory tract infection in patients receiving esomeprazole: retrospective analysis of adverse events in 31 clinical trials. Drug Saf 2008;31:627-636.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Filion KB, Chateau D, Targownik LE, et al. Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis. Gut 2014;63:552-558.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Sultan N, Nazareno J, Gregor J. Association between proton pump inhibitors and respiratory infections: a systematic review and meta-analysis of clinical trials. Can J Gastroenterol 2008;22:761-766.

  • Williams C, McColl KE. Review article: proton pump inhibitors and bacterial overgrowth. Aliment Pharmacol Ther 2006;23:3-10.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Laine L, Ahnen D, McClain C, Solcia E, Walsh JH. Review article: potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors. Aliment Pharmacol Ther 2000;14:651-668.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Bavishi C, Dupont HL. Systematic review: the use of proton pump inhibitors and increased susceptibility to enteric infection. Aliment Pharmacol Ther 2011;34:1269-1281.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Brophy S, Jones KH, Rahman MA, et al. Incidence of Campylobacter and Salmonella infections following first prescription for PPI: a cohort study using routine data. Am J Gastroenterol 2013;108:1094-1100.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Faleck DM, Salmasian H, Furuya EY, Larson EL, Abrams JA, Freedberg DE. Proton Pump Inhibitors Do Not Increase Risk for Clostridium difficile Infection in the Intensive Care Unit. Am J Gastroenterol 2016;111:1641-1648.

  • Khanna S, Aronson SL, Kammer PP, Baddour LM, Pardi DS. Gastric acid suppression and outcomes in Clostridium difficile infection: a population-based study. Mayo Clin Proc 2012;87:636-642.

  • Shivashankar R, Khanna S, Kammer PP, et al. Clinical factors associated with development of severe-complicated Clostridium difficile infection. Clin Gastroenterol Hepatol 2013;11:1466-1471.

  • Linsky A, Gupta K, Lawler EV, Fonda JR, Hermos JA. Proton pump inhibitors and risk for recurrent Clostridium difficile infection. Arch Intern Med 2010;170:772-778.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Freedberg DE, Salmasian H, Friedman C, Abrams JA. Proton pump inhibitors and risk for recurrent Clostridium difficile infection among inpatients. Am J Gastroenterol 2013;108:1794-1801.

  • Lundell L, Vieth M, Gibson F, Nagy P, Kahrilas PJ. Systematic review: the effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment Pharmacol Ther 2015;42:649-663.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Campana D, Ravizza D, Ferolla P, et al. Risk factors of type 1 gastric neuroendocrine neoplasia in patients with chronic atrophic gastritis. A retrospective, multicentre study. Endocrine 2017;56:633-638.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Lamberts R. Morphological changes of the human gastric mucosa under long-term proton pump inhibitor therapy and their clinical relevance. Microsc Res Tech 2000;48:357-366.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Delle Fave G, Capurso G, Annibale B, Panzuto F. Gastric neuroendocrine tumors. Neuroendocrinology 2004;80(suppl 1):16-19.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Yu JY, Wang LP, Meng YH, Hu M, Wang JL, Bordi C. Classification of gastric neuroendocrine tumors and its clinicopathologic significance. World J Gastroenterol 1998;4:158-161.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Sato Y, Imamura H, Kaizaki Y, et al. Management and clinical outcomes of type I gastric carcinoid patients: retrospective, multicenter study in Japan. Dig Endosc 2014;26:377-384.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Olbe L, Carlsson E, Lindberg P. A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole. Nat Rev Drug Discov 2003;2:132-139.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Dawson R, Manson JM. Omeprazole in oesophageal reflux disease. Lancet 2000;356:1770-1771.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Haga Y, Nakatsura T, Shibata Y, et al. Human gastric carcinoid detected during long-term antiulcer therapy of H2 receptor antagonist and proton pump inhibitor. Dig Dis Sci 1998;43:253-257.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Chiba T, Fukui H, Kinoshita Y. Reg protein: a possible mediator of gastrin-induced mucosal cell growth. J Gastroenterol 2000;35(suppl 12):52-56.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Kinoshita Y, Ishihara S, Kadowaki Y, Fukui H, Chiba T. Reg protein is a unique growth factor of gastric mucosal cells. J Gastroenterol 2004;39:507-513.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Gillen D, Wirz AA, Ardill JE, McColl KE. Rebound hypersecretion after omeprazole and its relation to on-treatment acid suppression and Helicobacter pylori status. Gastroenterology 1999;116:239-247.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Poitras P, Gingras MH, Rehfeld JF. The Zollinger-Ellison syndrome: dangers and consequences of interrupting antisecretory treatment. Clin Gastroenterol Hepatol 2012;10:199-202.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Jackson MA, Goodrich JK, Maxan ME, et al. Proton pump inhibitors alter the composition of the gut microbiota. Gut 2016;65:749-756.

  • Imhann F, Bonder MJ, Vich Vila A, et al. Proton pump inhibitors affect the gut microbiome. Gut 2016;65:740-748.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Mishiro T, Oka K, Kuroki Y, et al. Proton pump inhibitor alters oral microbiome in gastrointestinal tract of healthy volunteers. J Gastroenterol Hepatol. Published Online First: 4 Nov 2017

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Lo WK, Chan WW. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol 2013;11:483-490.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • William JH, Danziger J. Proton-pump inhibitor-induced hypomagnesemia: current research and proposed mechanisms. World J Nephrol 2016;5:152-157.

  • Hoorn EJ, van der Hoek J, de Man RA, Kuipers EJ, Bolwerk C, Zietse R. A case series of proton pump inhibitor-induced hypomagnesemia. Am J Kidney Dis 2010;56:112-116.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Biyik M, Solak Y, Ucar R, et al. Hypomagnesemia among outpatient long-term proton pump inhibitor users. Am J Ther 2017;24:e52-e55.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Cheungpasitporn W, Thongprayoon C, Kittanamongkolchai W, et al. Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies. Ren Fail 2015;37:1237-1241.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Bai JPF, Hausman E, Lionberger R, Zhang X. Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis. 1.Oral absorption of magnesium. Mol Pharm 2012;9:3495-3505.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Koop H, Bachem MG. Serum iron, ferritin, and vitamin B12 during prolonged omeprazole therapy. J Clin Gastroenterol 1992;14:288-292.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Stewart CA, Termanini B, Sutliff VE, et al. Iron absorption in patients with Zollinger-Ellison syndrome treated with long-term gastric acid antisecretory therapy. Aliment Pharmacol Ther 1998;12:83-98.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Hutchinson C, Geissler CA, Powell JJ, Bomford A. Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis. Gut 2007;56:1291-1295.

  • Vanclooster A, van Deursen C, Jaspers R, Cassiman D, Koek G. Proton pump inhibitors decrease phlebotomy need in HFE hemochromatosis: double-blind randomized placebo-controlled trial. Gastroenterology 2017;153:678-680, e2.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Wood RJ, Serfaty-Lacrosniere C. Gastric acidity, atrophic gastritis, and calcium absorption. Nutr Rev 1992;50:33-40.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Hansen KE, Jones AN, Lindstrom MJ, et al. Do proton pump inhibitors decrease calcium absorption?. J Bone Miner Res 2010;25:2786-2795.

  • Ngamruengphong S, Leontiadis GI, Radhi S, Dentino A, Nugent K. Proton pump inhibitors and risk of fracture: a systematic review and meta-analysis of observational studies. Am J Gastroenterol 2011;106:1209-1218.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Yu EW, Blackwell T, Ensrud KE, et al. Acid-suppressive medications and risk of bone loss and fracture in older adults. Calcif Tissue Int 2008;83:251-259.

  • Gray SL, LaCroix AZ, Larson J, et al. Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women’s Health Initiative. Arch Intern Med 2010;170:765-771.

  • Targownik LE, Lix LM, Leung S, Leslie WD. Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss. Gastroenterology 2010;138:896-904.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Targownik LE, Leslie WD, Davison KS, et al. The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: a population-based study [corrected] from the Canadian Multicentre Osteoporosis Study (CaMos). Am J Gastroenterol 2012;107:1361-1369.

  • Kaye JA, Jick H. Proton pump inhibitor use and risk of hip fractures in patients without major risk factors. Pharmacotherapy 2008;28:951-959.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Corley DA, Kubo A, Zhao W, Quesenberry C. Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients. Gastroenterology 2010;139:93-101.

  • Hirschowitz BI, Worthington J, Mohnen J. Vitamin B12 deficiency in hypersecretors during long-term acid suppression with proton pump inhibitors. Aliment Pharmacol Ther 2008;27:1110-1121.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Attwood SE, Ell C, Galmiche JP, et al. Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studies. Aliment Pharmacol Ther 2015;41:1162-1174.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA 2013;310:2435-2442.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Hartman B, Donnelly-VanderLoo M, Watson T, O’Connor C, Madill J. Proton-pump inhibitor therapy and vitamin B12 status in an inpatient hospital setting. Appl Physiol Nutr Metab 2016;41:1071-1076.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

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    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Ally MR, Veerappan GR, Maydonovitch CL, et al. Chronic proton pump inhibitor therapy associated with increased development of fundic gland polyps. Dig Dis Sci 2009;54:2617-2622.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Tran-Duy A, Spaetgens B, Hoes AW, de Wit NJ, Stehouwer CD. Use of proton pump inhibitors and risks of fundic gland polyps and gastric cancer: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2016;14:1706-1719, e5.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Torbenson M, Lee JH, Cruz-Correa M, et al. Sporadic fundic gland polyposis: a clinical, histological, and molecular analysis. Mod Pathol 2002;15:718-723.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Choudhry U, Boyce HW, Coppola D. Proton pump inhibitor-associated gastric polyps: a retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics. Am J Clin Pathol 1998;110:615-621.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med 1996;334:1018-1022.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Brunner G, Athmann C, Schneider A. Long-term, open-label trial: safety and efficacy of continuous maintenance treatment with pantoprazole for up to 15 years in severe acid-peptic disease. Aliment Pharmacol Ther 2012;36:37-47.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Poulsen AH, Christensen S, McLaughlin JK, et al. Proton pump inhibitors and risk of gastric cancer: a population-based cohort study. Br J Cancer 2009;100:1503-1507.

  • Brusselaers N, Wahlin K, Engstrand L, Lagergren J. Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden. BMJ Open 2017;7:e017739.

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    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Colucci R, Blandizzi C, Tanini M, Vassalle C, Breschi MC, Del Tacca M. Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. Br J Pharmacol 2005;144:338-348.

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    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Singh M, Dhindsa G, Friedland S, Triadafilopoulos G. Long-term use of proton pump inhibitors does not affect the frequency, growth, or histologic characteristics of colon adenomas. Aliment Pharmacol Ther 2007;26:1051-1061.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Yang YX, Hennessy S, Propert K, Hwang WT, Sedarat A, Lewis JD. Chronic proton pump inhibitor therapy and the risk of colorectal cancer. Gastroenterology 2007;133:748-754.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Robertson DJ, Larsson H, Friis S, Pedersen L, Baron JA, Sørensen HT. Proton pump inhibitor use and risk of colorectal cancer: a population-based, case-control study. Gastroenterology 2007;133:755-760.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Yu T, Tang Y, Jiang L, Zheng Y, Xiong W, Lin L. Proton pump inhibitor therapy and its association with spontaneous bacterial peritonitis incidence and mortality: a meta-analysis. Dig Liver Dis 2016;48:353-359.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Khan MA, Kamal S, Khan S, Lee WM, Howden CW. Systematic review and meta-analysis of the possible association between pharmacological gastric acid suppression and spontaneous bacterial peritonitis. Eur J Gastroenterol Hepatol 2015;27:1327-1336.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Dam G, Vilstrup H, Watson H, Jepsen P. Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites. Hepatology 2016;64:1265-1272.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Kim JH, Lim KS, Min YW, et al. Proton pump inhibitors do not increase the risk for recurrent spontaneous bacterial peritonitis in patients with cirrhosis. J Gastroenterol Hepatol 2017;32:1064-1070.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Terg R, Casciato P, Garbe C, et al. Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study. J Hepatol 2015;62:1056-1060.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Okamoto E, Amano Y, Fukuhara H, et al. Does gastroesophageal reflux have an influence on bleeding from esophageal varices?. J Gastroenterol 2008;43:803-808.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Hidaka H, Nakazawa T, Wang G, et al. Long-term administration of PPI reduces treatment failures after esophageal variceal band ligation: a randomized, controlled trial. J Gastroenterol 2012;47:118-126.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Goh KL, Choi MG, Hsu PI, et al. Pharmacological and safety profile of dexlansoprazole: a new proton pump inhibitor-implications for treatment of gastroesophageal reflux disease in the Asia Pacific region. J Neurogastroenterol Motil 2016;22:355-366.

  • Xie C, Sifrim D, Li Y, Chen M, Xiao Y. Esophageal baseline impedance reflects mucosal integrity and predicts symptomatic outcome with proton pump inhibitor treatment. J Neurogastroenterol Motil 2018;24:43-50.

    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids
    Which phrase describes how histamine 2 receptor antagonists reduce the secretion of acids

  • Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterology 2017;152:706-715.

    What is the action of H2

    what are the INDICATIONS for H2 Receptor Antagonists (H2RA)? * blocks the histamine 2 receptors, on the parietal cells of stomach, from secreting gastric acid - therefore decrease gastric acid output regardless of stimulants such as histamine, food, insulin and caffeine.

    Which of the following is a histamine H2 receptor antagonist?

    Histamine-2 Receptor Antagonists Commonly used H2RAs include famotidine, cimetidine, nizatidine, and ranitidine.

    Which histamine 2 antagonist is associated with the most drug interactions?

    tidine is the H2-receptor antagonist that has been most often associated with clinically significant drug- drug interactions; however, studies show that ranitidine to a lesser ex- tent also presents problems. To date, significant interactions with nizatidine or famotidine have not been reported.

    What is true of acid control therapy with H2 blockers?

    What H2 blockers do is stop the acid-making cells in the stomach lining from responding to histamine. This reduces the amount of acid produced by your stomach. By decreasing the amount of acid, H2 blockers can help to reduce acid reflux-related symptoms such as heartburn.

    • phrase describes histamine receptor antagonists reduce secretion acids

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