Drug information provided by: IBM Micromedex Show
It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects. You will also need to have your blood pressure measured before starting this medicine and while you are using it. If you notice any change to your recommended blood pressure, call your doctor right away. If you have questions about this, talk to your doctor. When taken with certain foods, drinks, or other medicines, phenelzine can cause very dangerous reactions, such as sudden high blood pressure (also called hypertensive crisis). To avoid such reactions, follow these rules of caution:
Phenelzine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away. Call your doctor or hospital emergency room right away if you have a severe headache, stiff or sore neck, chest pains, fast heartbeat, sweating, dizziness, or nausea and vomiting while you are taking this medicine. These may be symptoms of a serious side effect called hypertensive crisis. This medicine may cause blurred vision or make some people drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are unable to see well or not alert. This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. When you get up from lying down, sit on the edge of the bed with your feet dangling for 1 or 2 minutes, then stand up slowly. If the problem continues or gets worse, check with your doctor. Do not stop taking this medicine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine or have used it within the past 10 days. Taking phenelzine together with medicines that are used during surgery, dental, or emergency treatments may increase the risk of serious side effects. Your doctor may want you to carry an identification card stating that you are using this medicine. This medicine may affect blood sugar levels. If you are diabetic, be especially careful in testing for sugar in your blood or urine. If you have any questions about this, check with your doctor. After you stop using this medicine, you must continue to exercise caution for at least 2 weeks with your foods, drinks, and other medicines, since these items may continue to react with phenelzine. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Portions of this document last updated: Nov. 01, 2022 Copyright © 2023 IBM Watson Health. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. . What is Antivert and how is it used?Antivert is an over the counter and prescription medicine used to treat the symptoms of motion sickness and vertigo. Antivert may be used alone or with other medications. Antivert belongs to a class of drugs called Atiemetic Agents; Antiemetics, Antihistamine. It is not known if Antivert is safe and effective in children younger than 12 years of age. What are the possible side effects of Antivert?Antivert may cause serious side effects including:
Get medical help right away, if you have any of the symptoms listed above. The most common side effects of Antivert include:
Tell the doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Antivert. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. DESCRIPTIONChemically, ANTIVERT® (meclizine HCl) is 1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl) piperazine dihydrochloride monohydrate.  Inert ingredients for the tablets are: dibasic calcium phosphate; magnesium stearate; polyethylene glycol; starch; sucrose. The 12.5 mg tablets also contain: Blue 1. The 25 mg tablets also contain: Yellow 6 Lake; Yellow 10 Lake. The 50 mg tablets also contain: BLUE 1 Lake; Yellow 10 Lake. 2 pharmacies near 55442 have coupons for Bonine (Brand Names:Antivert for 8 Tablets)INDICATIONSANTIVERT is indicated for the treatment of vertigo associated with diseases affecting the vestibular system. DOSAGE AND ADMINISTRATIONFor the treatment of vertigo associated with diseases affecting the vestibular system, the recommended dose is 25 to 100 mg daily, in divided dosage, depending upon clinical response. HOW SUPPLIEDAntivert® 12.5 mg tablets: Bottles of 100 - NDC 70199-002-01 Antivert® 25 mg tablets: Bottles of 100 - NDC 70199-003-01 Antivert® 50 mg tablets: Bottles of 100 - NDC 70199-004-01 Manufactured for: Casper Pharma LLC. East Brunswick, NJ 08816. Revised: Apr 2018. QUESTIONWhat is vertigo? See AnswerSide Effects & Drug Interactions SIDE EFFECTSAnaphylactoid reaction, drowsiness, dry mouth, headache, fatigue, vomiting and, on rare occasions, blurred vision have been reported. To report SUSPECTED ADVERSE REACTIONS, contact Casper Pharma LLC. at 1-844– 5–CASPER (1-844-522-7737) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. DRUG INTERACTIONSThere may be increased CNS depression when meclizine is administered concurrently with other CNS depressants, including alcohol, tranquilizers, and sedatives. (see WARNINGS). Based on in-vitro evaluation, meclizine is metabolized by CYP2D6. Therefore there is a possibility for a drug interaction between meclizine and CYP2D6 inhibitors. WARNINGSSince drowsiness may, on occasion, occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery. Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma, or enlargement of the prostate gland. PRECAUTIONSPediatric UseClinical studies establishing safety and effectiveness in children have not been done; therefore, usage is not recommended in children under 12 years of age. PregnancyPregnancy Category BReproduction studies in rats have shown cleft palates at 25–50 times the human dose. Epidemiological studies in pregnant women, however, do not indicate that meclizine increases the risk of abnormalities when administered during pregnancy. Despite the animal findings, it would appear that the possibility of fetal harm is remote. Nevertheless, meclizine, or any other medication, should be used during pregnancy only if clearly necessary. Nursing MothersIt is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when meclizine is administered to a nursing woman. Hepatic ImpairmentThe effect of hepatic impairment on the pharmacokinetics of meclizine has not been evaluated. As meclizine undergoes metabolism, hepatic impairment may result in increased systemic exposure of the drug. Treatment with meclizine should be administered with caution in patients with hepatic impairment. Renal ImpairmentThe effect of renal impairment on the pharmacokinetics of meclizine has not been evaluated. Due to a potential for drug/metabolite accumulation, meclizine should be administered with caution in patients with renal impairment and in the elderly as renal function generally declines with age. Overdose & Contraindications OVERDOSENo Information Provided CONTRAINDICATIONSMeclizine HCl is contraindicated in individuals who have shown a previous hypersensitivity to it. CLINICAL PHARMACOLOGYANTIVERT is an antihistamine that shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholine. Its activity is relatively weak in inhibiting the spasmogenic action of histamine on isolated guinea pig ileum. PharmacokineticsThe available pharmacokinetic information for meclizine following oral administration has been summarized from published literature. AbsorptionMeclizine is absorbed after oral administration with maximum plasma concentrations reaching at a median Tmax value of 3 hours post-dose (range: 1.5 to 6 hours) for the tablet dosage form. DistributionDrug distribution characteristics for meclizine in humans are unknown. MetabolismThe metabolic fate of meclizine in humans is unknown. In an in vitro metabolic study using human hepatic microsome and recombinant CYP enzyme, CYP2D6 was found to be the dominant enzyme for metabolism of meclizine. The genetic polymorphism of CYP2D6 that results in extensive-, poor-, intermediate- and ultrarapid metabolizer phenotypes could contribute to large inter-individual variability in meclizine exposure. EliminationMeclizine has a plasma elimination half-life of about 5-6 hours in humans. PATIENT INFORMATIONNo information provided. Please refer to the WARNINGSand PRECAUTIONS sections. From Report Problems to the Food and Drug AdministrationYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088. What would increase the risk of sedation in a patient receiving meclizine?Ethanol intake will increase the risk of sedation. Sedating antihistamines can also cause a paradoxical CNS stimulation; although, this is more likely to occur in children. Symptoms may include excitability, insomnia, irritability, restlessness, palpitations, nervousness, and in severe cases, seizures.
What is the most common adverse reaction the nurse would expect in a client receiving an antiemetic?Antiemetics are generally well-tolerated, but can have potential side effects, such as constipation or diarrhea, headache, fatigue, malaise, dizziness, light-headedness, blurred vision, dry mouth, or photosensitivity.
What are the most common adverse effects associated with drug therapy?Some common examples mild adverse effects related to drugs include:. Constipation.. Skin rash or dermatitis.. Diarrhea.. Dizziness.. Drowsiness.. Dry mouth.. Headache.. Insomnia.. Which would the nurse anticipate to be used for the prevention of nausea from motion sickness?Scopolamine is a medication used in the management and treatment of motion sickness and postoperative nausea/vomiting.
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A client is receiving meclizine. the nurse would caution the client to avoid:
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