1. Bayliss WM, Starling EH. The movements and innervation of the small intestine. J Physiol. 1899;24:99–143. [PMC free article] [PubMed] [Google Scholar]
2. Kerlin P, Zinsmeister A, Phillips S. Relationship of motility to flow of contents in the human small intestine. Gastroenterology. 1982;82:701–706. [PubMed] [Google Scholar]
3. Tremolaterra F, Villoria A, Serra J, et al. Intestinal tone and gas motion. Neurogastroenterol Motil. 2006;18:905–910. [PubMed] [Google Scholar]
4. Plavsic BM, Robinson AE, Jeffrey RB. Gastrointestinal Radiology. McGraw-Hill; New York, NY: 1992. [Google Scholar]
5. Lönnerblad L. Transit time through small intestine: roentgenologic study on normal variability. Acta Radiologica - Supplementum. 1951;88:1–85. [PubMed] [Google Scholar]
6. Thompson WM, Halvorsen RA, Shaw M, et al. Evaluation of intramuscular ceruletide for shortening small bowel transit time. Gastrointest Radiol. 1982;7:141–147. [PubMed] [Google Scholar]
7. Kim SK. Small intestine transit time in the normal small bowel study. AJR. 1968;104:522–524. [PubMed] [Google Scholar]
8. Richards DG, Stevenson GW. Laxatives prior to small bowel follow-through: are they necessary for a rapid and good-quality examination? Gastrointest Radiol. 1990;15:66–68. [PubMed] [Google Scholar]
9. Summers DS, Roger MD, Allan PL, et al. Accelerating the transit time of barium sulphate suspensions in small bowel examinations. Eur J Radiol. 2007;62:122–125. [PubMed] [Google Scholar]
10. Sampson MA, deLacey G, Twomey B, et al. The small bowel follow-through: time to sit up. Clin Radiol. 1994;49:478–487. [PubMed] [Google Scholar]
11. Brady AP. Use of effervescent agents in small bowel meal examination. Clin Radiol. 1994;49:434–435. [PubMed] [Google Scholar]
12. Fraser GM, Adam RD. Modifications to the gas-enhanced small bowel barium follow-through using Gastrografin and compression. Clin Radiol. 1988;39:537–554. [PubMed] [Google Scholar]
13. Paul N, Rawlinson J, Keir M. The use of metoclopramide for the small bowel meal examination: pre-procedural versus peri-procedural oral administration. Br J Radiol. 1996;69:1130–1133. [PubMed] [Google Scholar]
14. James WB, Hume R. Action of metoclopramide on gastric emptying and small bowel transit time. Gut. 1968;9:203–205. [PMC free article] [PubMed] [Google Scholar]
15. James WB, Melrose AG. Metoclopramide in gastro-intestinal radiology. Clin Radiol. 1969;20:57–60. [PubMed] [Google Scholar]
16. Bond JH, Levitt MP. Investigation of small bowel transit time in man utilizing pulmonary hydrogen measurements. J Lab Clin Med. 1975;85:546–555. [PubMed] [Google Scholar]
17. Camboni G, Basilisco G, Bozzani A, et al. Repeatability of lactulose hydrogen breath test in subjects with normal or prolonged orocecal transit. Dig Dis Sci. 1988;33:1525–1527. [PubMed] [Google Scholar]
18. Hirakawa M, Iida M, Kohrogi N, et al. Hydrogen breath test assessment of orocecal transit time: comparison with barium meal study. Am J Gastroenterol. 1988;83:1361–1363. [PubMed] [Google Scholar]
19. Yu D, Cheeseman F, Vanner S. Combined oro-caecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects oro-caecal transit, not small intestinal bacterial overgrowth in patients with IBS. Gut. 2011;60:334–340. [PubMed] [Google Scholar]
20. Sciarretta G, Furno A, Mazzoni M, et al. Lactulose hydrogen breath test in orocecal transit assessment. Critical evaluation by means of scintigraphic method. Dig Dis Sci. 1994;39:1505–1510. [PubMed] [Google Scholar]
21. van Nieuwenhoven MA, Kovacs EM, Brummer RJ, et al. The effect of different dosages of guar gum on gastric emptying and small intestinal transit of a consumed semisolid meal. J Am Coll Nutr. 2001;20:87–91. [PubMed] [Google Scholar]
22. Ternent CA, Thorson AG, Blatchford GJ, et al. Mouth to pouch transit after restorative proctocolectomy: hydrogen breath analysis correlates with scintigraphy. Am J Gastroenterol. 2001;96:1460–1463. [PubMed] [Google Scholar]
23. Staniforth DH. Effect of drugs on oro-caecal transit time assessed by the lactulose/breath hydrogen method. Eur J Clin Pharmacol. 1987;33:55–58. [PubMed] [Google Scholar]
24. Yuan CS, Foss JF, O'Connor M, et al. Gut motility and transit changes in patients receiving long-term methadone maintenance. J Clin Pharmacol. 1998;38:931–935. [PubMed] [Google Scholar]
25. Yuan CS, Foss JF, Osinski J, et al. The safety and efficacy of oral methylnaltrexone in preventing morphine-induced delay in oral-cecal transit time. Clin Pharmacol Ther. 1997;61:467–475. [PubMed] [Google Scholar]
26. Gorard DA, Libby GW, Farthing MJ. Effect of a tricyclic antidepressant on small intestinal motility in health and diarrhea-predominant irritable bowel syndrome. Dig Dis Sci. 1995;40:86–95. [PubMed] [Google Scholar]
27. Morali GA, Braverman DZ, Lissi J, et al. Effect of clonidine on gallbladder contraction and small bowel transit time in insulin-treated diabetics. Am J Gastroenterol. 1991;86:995–999. [PubMed] [Google Scholar]
28. Soares AC, Lederman HM, Fagundes-Neto U, et al. Breath hydrogen test after a bean meal demonstrates delayed oro-cecal transit time in children with chronic constipation. J Pediatr Gastroenterol Nutr. 2005;41:221–224. [PubMed] [Google Scholar]
29. Ghoshal UC, Ghoshal U, Ayyagari A, et al. Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time. J Gastroenterol Hepatol. 2003;18:540–547. [PubMed] [Google Scholar]
30. Lorena SL, de Souza Almeida JR, Mesquita MA. Orocecal transit time in patients with functional dyspepsia. J Clin Gastroenterol. 2002;35:21–24. [PubMed] [Google Scholar]
31. Iivonen MK, Ahola TO, Matikainen MJ. Bacterial overgrowth, intestinal transit, and nutrition after total gastrectomy. Comparison of a jejunal pouch with Roux-en-Y reconstruction in a prospective random study. Scand J Gastroenterol. 1998;33:63–70. [PubMed] [Google Scholar]
32. Vajro P, Silano G, Longo D, et al. Orocoecal transit time in healthy and constipated children. Acta Paediatrica Scandinavica. 1988;77:583–586. [PubMed] [Google Scholar]
34. Read NW, Miles CA, Fisher D, et al. Transit of a meal through the stomach, small intestine and colon in normal subjects and its role in the pathogenesis of diarrhea. Gastroenterology. 1980;79:1276–1282. [PubMed] [Google Scholar]
35. Miller MA, Parkman HP, Urbain JL, et al. Comparison of scintigraphy and lactulose breath hydrogen test for assessment of orocecal transit: lactulose accelerates small bowel transit. Dig Dis Sci. 1997;42:10–18. [PubMed] [Google Scholar]
36. Geboes KP, Luypaerts A, Rutgeerts P, et al. Inulin is an ideal substrate for a hydrogen breath test to measure the orocaecal transit time. Aliment Pharmacol Ther. 2003;18:721–729. [PubMed] [Google Scholar]
37. Schneider AR, Jepp K, Murczynski L, et al. The inulin hydrogen breath test accurately reflects orocaecal transit time. Eur J Clin Invest. 2007;37:802–807. [PubMed] [Google Scholar]
38. Heine WE, Berthold HK, Klein PD. A novel stable isotope breath test: 13C-labeled glycosyl ureides used as noninvasive markers of intestinal transit time. Am J Gastroenterol. 1995;90:93–98. [PubMed] [Google Scholar]
39. Geypens B, Bennink R, Peeters M, et al. Validation of the lactose-[13C]ureide breath test for determination of orocecal transit time by scintigraphy. J Nucl Med. 1999;40:1451–1455. [PubMed] [Google Scholar]
40. Ruemmele FM, Heine WE, Keller KM, et al. Metabolism of glycosyl ureides by human intestinal brush border enzymes. Biochimica et Biophysica Acta. 1997;1336:275–280. [PubMed] [Google Scholar]
41. Coremans G, Vos R, Margaritis V, et al. Small doses of the unabsorbable substance polyethylene glycol 3350 accelerate oro-caecal transit, but slow gastric emptying in healthy subjects. Dig Liver Dis. 2005;37:97–101. [PubMed] [Google Scholar]
42. Priebe MG, Wachters-Hagedoorn RE, Landman K, et al. Influence of a subsequent meal on the oro-cecal transit time of a solid test meal. Eur J Clin Invest. 2006;36:123–126. [PubMed] [Google Scholar]
43. Cloetens L, De Preter V, Swennen K, et al. Dose-response effect of arabinoxylooligosaccharides on gastrointestinal motility and on colonic bacterial metabolism in healthy volunteers. J Am Coll Nutr. 2008;27:512–518. [PubMed] [Google Scholar]
44. Van Den Driessche M, Van Malderen N, Geypens B, et al. Lactose-[13C]ureide breath test: a new, noninvasive technique to determine orocecal transit time in children. J Pediatr Gastroenterol Nutr. 2000;31:433–438. [PubMed] [Google Scholar]
45. De Preter V, Verbeke K. Evaluation of the necessity of induction for lactose-[15N, 15N]-ureide to study the colonic ammonia metabolism. Scand J Gastroenterol. 2006;41:396–400. [PubMed] [Google Scholar]
46. Sadik R, Abrahamsson H, Bjornsson E, et al. Etiology of portal hypertension may influence gastrointestinal transit. Scand J Gastroenterol. 2003;38:1039–1044. [PubMed] [Google Scholar]
47. Stotzer PO, Abrahamsson H. Human postprandial gastric emptying of indigestible solids can occur unrelated to antral phase III. Neurogastroenterol Motil. 2000;12:415–419. [PubMed] [Google Scholar]
48. Sadik R, Abrahamsson H, Stotzer PO. Gender differences in gut transit shown with a newly developed radiological procedure. Scand J Gastroenterol. 2003;38:36–42. [PubMed] [Google Scholar]
49. Pecchi A, De Santis M, Torricelli P, et al. Radiologic imaging of the transplanted bowel. Abdominal Imaging. 2005;30:548–563. [PMC free article] [PubMed] [Google Scholar]
50. Tomita R, Fujisaki S, Tanjoh K. Relationship between gastrointestinal transit time and daily stool frequency in patients after Ileal J pouch-anal anastomosis for ulcerative colitis. Am J Surg. 2004;187:76–82. [PubMed] [Google Scholar]
51. Lin HC, Prather C, Fisher RS, et al. Measurement of gastrointestinal transit. Dig Dis Sci. 2005;50:989–1004. [PubMed] [Google Scholar]
52. Bonapace ES, Maurer AH, Davidoff S, et al. Whole gut transit scintigraphy in the clinical evaluation of patients with upper and lower gastrointestinal symptoms. Am J Gastroenterol. 2000;95:2838–2847. [PubMed] [Google Scholar]
53. Krevsky B, Maurer AH, Niewiarowski T, et al. Effect of verapamil on human intestinal transit. Dig Dis Sci. 1992;37:919–924. [PubMed] [Google Scholar]
54. Camilleri M, Zinsmeister AR, Greydanus MP, et al. Towards a less costly but accurate test of gastric emptying and small bowel transit. Dig Dis Sci. 1991;36:609–615. [PubMed] [Google Scholar]
55. Argenyi EE, Soffer EE, Madsen MT, et al. Scintigraphic evaluation of small bowel transit in healthy subjects: inter- and intrasubject variability. Am J Gastroenterol. 1995;90:938–942. [PubMed] [Google Scholar]
56. Bennink R, Peeters M, Van den Maegdenbergh V, et al. Evaluation of small-bowel transit for solid and liquid test meal in healthy men and women. Eur J Nucl Med. 1999;26:1560–1566. [PubMed] [Google Scholar]
57. Camilleri M, Hasler WL, Parkman HP, et al. Measurement of gastrointestinal motility in the GI laboratory. Gastroenterology. 1998;115:747–762. [PubMed] [Google Scholar]
58. Maurer AH, Krevsky B. Whole-gut transit scintigraphy in the evaluation of small-bowel and colonic transit disorders. Semin Nucl Med. 1995;25:326–338. [PubMed] [Google Scholar]
59. Grybäck P, Jacobsson H, Blomquist L, et al. Scintigraphy of the small intestine: a simplified standard for study of transit with reference to normal values. Eur J Nucl Med Mol Imaging. 2002;29:39–44. [PubMed] [Google Scholar]
60. Charles F, Camilleri M, Phillips SF, et al. Scintigraphy of the whole gut: clinical evaluation of transit disorders. Mayo Clin Proc. 1995;70:113–118. [PubMed] [Google Scholar]
61. Camilleri M, Zinsmeister AR. Towards a relatively inexpensive, noninvasive, accurate test for colonic motility disorders. Gastroenterology. 1992;103:36–42. [PubMed] [Google Scholar]
62. Cremonini F, Mullan BP, Camilleri M, et al. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharmacol Ther. 2002;16:1781–1790. [PubMed] [Google Scholar]
63. Deiteren A, Camilleri M, Bharucha AE, et al. Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions. Neurogastroenterol Motil. 2010;22:415–423. e95. [PMC free article] [PubMed] [Google Scholar]
64. Camilleri M, Brown ML, Malagelada JR. Impaired transit of chyme in chronic intestinal pseudoobstruction. Correction by cisapride. Gastroenterology. 1986;91:619–626. [PubMed] [Google Scholar]
65. Camilleri M, Malagelada JR, Abell TL, et al. Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudoobstruction. Gastroenterology. 1989;96:704–712. [PubMed] [Google Scholar]
66. Prather CM, Camilleri M, Zinsmeister AR, et al. Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Gastroenterology. 2000;118:463–468. [PubMed] [Google Scholar]
67. Balan K, Alwis L, Sonoda LI, et al. Utility of whole gut transit scintigraphy in patients with chronic gastrointestinal symptoms. Nucl Med Commun. 2010;31:328–333. [PubMed] [Google Scholar]
68. Rao SS, Camilleri M, Hasler WL, et al. Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil. 2011;23:8–23. [PubMed] [Google Scholar]
69. Kuo B, McCallum RW, Koch KL, et al. Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. Aliment Pharmacol Ther. 2008;27:186–196. [PubMed] [Google Scholar]
70. Cassilly D, Kantor S, Knight LC, et al. Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy. Neurogastroenterol Motil. 2008;20:311–319. [PubMed] [Google Scholar]
71. Kloetzer L, Chey WD, McCallum RW, et al. Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule. Neurogastroenterol Motil. 2010;22:527–533. e117. [PubMed] [Google Scholar]
72. Sarr MG, Kelly KA. Patterns of movement of liquids and solids through canine jejunum. Am J Physiol. 1980;239:G497–G503. [PubMed] [Google Scholar]
73. Quigley EM, Borody TJ, Phillips SF, et al. Motility of the terminal ileum and ileocecal sphincter in healthy humans. Gastroenterology. 1984;87:857–866. [PubMed] [Google Scholar]
74. Parkman HP, McCallum RW, Rao SSC. GI Motility Testing. Slack Inc; Thorofare, NJ: 2011. [Google Scholar]
75. Zarate N, Mohammed SD, O'Shaughnessy E, et al. Accurate localization of a fall in pH within the ileocecal region: validation using a dual-scintigraphic technique. Am J Physiol. 2010;299:G1276–G1286. [PubMed] [Google Scholar]
76. Sarosiek I, Selover KH, Katz LA, et al. The assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology. Aliment Pharmacol Ther. 2010;31:313–322. [PMC free article] [PubMed] [Google Scholar]
77. Camilleri M, Thorne NK, Ringel Y, et al. Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation. Neurogastroenterol Motil. 2010;22:874–882. e233. [PMC free article] [PubMed] [Google Scholar]
78. Timm D, Willis H, Thomas W, et al. The use of a wireless motility device (SmartPill®) for the measurement of gastrointestinal transit time after a dietary fibre intervention. Br J Nutr. 2011;105:1337–1342. [PubMed] [Google Scholar]
79. Rao SS, Kuo B, McCallum RW, et al. Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clin Gastroenterol Hepatol. 2009;7:537–544. [PubMed] [Google Scholar]
80. Hinton JM, Lennard-Jones JE, Young AC. A new method for studying gut transit times using radioopaque markers. Gut. 1969;10:842–847. [PMC free article] [PubMed] [Google Scholar]
81. Arhan P, Devroede G, Jehannin B, et al. Segmental colonic transit time. Dis Colon Rectum. 1981;24:625–629. [PubMed] [Google Scholar]
82. Metcalf AM, Phillips SF, Zinsmeister AR, et al. Simplified assessment of segmental colonic transit. Gastroenterology. 1987;92:40–47. [PubMed] [Google Scholar]
83. Evans RC, Kamm MA, Hinton JM, et al. The normal range and a simple diagram for recording whole gut transit time. Intl J Colorectal Dis. 1992;7:15–17. [PubMed] [Google Scholar]
84. Anuras S, editor. Motility Disorders of the Gastrointestinal Tract: Principles and Practice. Raven Press; New York, NY: 1992. p. 129. [Google Scholar]
85. Sadik R, Stotzer PO, Simrén M, et al. Gastrointestinal transit abnormalities are frequently detected in patients with unexplained GI symptoms at a tertiary centre. Neurogastroenterol Motil. 2008;20:197–205. [PubMed] [Google Scholar]
86. Rao SSC. Constipation: evaluation and treatment of colonic and anorectal motility disorders. GE Clin NA. 2007;36:687–711. [PubMed] [Google Scholar]
87. Proano M, Camilleri M, Phillips SF, et al. Transit of solids through the human colon: regional quantification in the unprepared bowel. Am J Physiol. 1990;258:G856–G862. [PubMed] [Google Scholar]
88. Burton DD, Camilleri M, Mullan BP, et al. Colonic transit scintigraphy labeled activated charcoal compared with ion exchange pellets. J Nucl Med. 1997;38:1807–1810. [PubMed] [Google Scholar]
89. Deiteren A, Camilleri M, Burton D, et al. Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome. Dig Dis Sci. 2010;55:384–391. [PMC free article] [PubMed] [Google Scholar]
90. Spiller RC, Brown ML, Phillips SF. Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility. Gastroenterology. 1987;92:724–729. [PubMed] [Google Scholar]
91. Stivland T, Camilleri M, Vassallo M, et al. Scintigraphic measurement of regional gut transit in idiopathic constipation. Gastroenterology. 1991;101:107–115. [PubMed] [Google Scholar]
92. Vassallo M, Camilleri M, Phillips SF, et al. Transit through the proximal colon influences stool weight in the irritable bowel syndrome. Gastroenterology. 1992;102:102–108. [PubMed] [Google Scholar]
94. Cremonini F, Mullan BP, Camilleri M, et al. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharm Ther. 2002;16:1781–1790. [PubMed] [Google Scholar]
95. von der Ohe M, Camilleri M, Kvols LK, et al. Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. N Engl J Med. 1993;329:1073–1078. [PubMed] [Google Scholar]
96. Camilleri M, McKinzie S, Busciglio I, et al. Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2008;6:772–781. [PMC free article] [PubMed] [Google Scholar]
97. Camilleri M. Scintigraphic biomarkers for colonic dysmotility. Clin Pharmacol Ther. 2010;87:748–753. [PMC free article] [PubMed] [Google Scholar]
98. Manabe N, Cremonini F, Camilleri M, et al. Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers. Aliment Pharmacol Ther. 2009;30:930–936. [PMC free article] [PubMed] [Google Scholar]
99. Sweetser S, Camilleri M, Linker Nord SJ, et al. Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome? Am J Physiol. 2009;296:G1299–G1306. [PMC free article] [PubMed] [Google Scholar]
100. Grudell AB, Camilleri M, Jensen KL, et al. Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health. Am J Physiol. 2008;294:G1114–G1119. [PubMed] [Google Scholar]
101. Hasler WL, Saad RJ, Rao SR, et al. Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS. Am J Physiol. 2009;297:G1107–G1114. [PubMed] [Google Scholar]